The Ighv3-73 gene has been identified in macaques, encoding wildcard antibodies capable of recognizing parts of the more conserved spike protein. According to the authors, these are important steps for getting better vaccines
Scientists from the US Scripps Research Institute ‘Pan-coronavirus’ antibody discovered in macaques ‘effective against many different variants of Sars-CoV-2’, but also “against other SARS viruses such as SARS-CoV-1, the highly lethal pathogen responsible for the 2003 epidemic”. The study, published in Science Translational Medicine, notes that “some animals are surprisingly more capable of producing this type of anti-Pan-Sars virus” than humans, “providing researchers” with clues about how to develop them.
“If we could design vaccines that elicit broad ‘immune’ responses, similar to those shown ‘in the new work,’ they could ensure greater protection against the virus.”
“And the variables of concern,” says the senior author. Raiees AndrabiScripps researcher in the Department of Immunology and Microbiology.
The “wildcard” antibody It was identified in the study to identify a relatively conserved fragment of the viral spike protein, which is found in many different SARS viruses and is less likely to mutate over time. An ingredient that the authors consider useful in developing “next-generation vaccines”, which are “capable of providing additional protection against emerging variants of SARS-CoV-2 and against other SARS viruses”.
In the study, rhesus macaques were immunized with the spike protein Sars-CoV-2, the hook that the virus uses to attach to and infect target cells. was managed two dosesAccording to a strategy similar to that adopted with mRna vaccines against Covid. Differently from what occurs in humans after ingestion of these products, it has been observed, however, that macaques have developedExtensive antibody response against the virus, including variants such as Omicron. Intrigued by this apparent difference, the scientists decided to examine the structure of the macaques’ superantibodies, discovering that They recognize a spike region different from the targets of most human antibodies: a more conserved region, in fact, located more laterally at the edge of the junction point between the Spike and the Ace2 receptor of our cells. This is an “important area, common to many SARS viruses, which have rarely been the target of human antibodies until now,” the study’s senior author highlights. Ian Wilsonhead of the Scripps Division of Integrated Structural and Computational Biology, who suggests the opportunity to study “additional strategies that can be exploited to persuade our immune system to recognize this specific region of the virus.”
The jane macaques who – which This superantibodies encode for neutralizing Against SARS – the authors also note – is IGF 3-73, differs from the Ighv3-53 gene that regulates the human immune response, and is robust, but with a much narrower spectrum. According to the researchers, understanding this could help design vaccines, or adjuvant vaccine formulations, that induce broader protection against SARS-CoV-2 and its many variants. «From our study – comments of the first co-author Dennis BurtonHead of the Department of Immunology and Microbiology at Scripps – it turns out Macaques have antibody genes that provide them with greater protection against SARS viruses. This observation sets a new goal for our vaccine efforts, which we may be able to achieve using advanced protein design methods. “
Aug 10, 2022 (change on Aug 10, 2022 | 20:22)
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