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Positive in Covid for more than a year: in the UK the first case in the world

It documented the longest infection of SARS-CoV-2 ever: lasting 505 days, it captured an immunosuppressed patient, who then did not succeed despite treatments. The case report was presented in Lisbon at the conference of the European Society of Clinical Microbiology and Infectious Diseases by experts from King’s College London, Guy’s and St Thomas’ NHS Foundation Trust, and the case report reinforces the notion of the formation of new Covid variants in these patients. to heal.

And this is not an isolated case: the study presented in Portugal actually followed 9 of these patients with very long COVID-19, all of whom were immunosuppressed due to diseases (HIV, tumors, etc.) or ongoing treatments (with inhibitors immunity). The study, conducted by Luke Blagdon Snell, documented the first case of occult infection, that is, of a patient who, after having tested negative in several tests, was reintroduced into a variant that is no longer circulating, which indicates the fact that the virus remained hidden in the body for a long time.

The experts periodically sequenced the virus in nine patients and checked for mutations to appear over time in variants known as alpha, delta and omicron. Five of the nine patients survived. Two of them defeated the virus on their own, two after receiving monoclonal and antiviral antibodies, and the last one remained infected for more than a year (412 days), despite antibody treatment.

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Earl Warner

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